Startup spotlight

XDMD

Developing AI for medical imaging 

In the rapidly evolving world of healthcare, the primary bottleneck isn’t a lack of scientific discovery, it’s the engineering gap. While academic research consistently produces groundbreaking AI methodologies for medical imaging, a vast majority of these innovations never leave the whiteboard. Transforming a theoretical model into a robust, scalable tool that functions within the high-stakes environment of a clinic requires a fusion of rigorous engineering discipline and deep clinical context.

XDMD was founded to solve this translation problem. They are an engineering company focused on medical imaging. They build custom-made AI solutions in close collaboration with clinical and industrial partners for radiology, pathology or any other domain where medical images are used. The company combines strong engineering discipline with deep domain understanding, helping their clients to achieve state-of-the-art performance and faster time-to-market.

Meet the team

Dr.ir. Rashindra Manniesing is the founder of XDMD. He previously spent his career as an academic researcher in medical imaging, authoring over 70 publications in the field.

Dr. Gastón Creci is the AI engineer of XDMD. With a background in theoretical physics, he approaches medical imaging from first principles.

XDMD is supported by an advisory board of leading scientists in medical imaging and AI, including Prof. Chris de Korte (Radboudumc), Prof. Jonas Teuwen (Netherlands Cancer Institute), Prof. Marcel van Gerven (Radboud/Donders), , and Prof. Thijs Vande Vyvere (Antwerp University Hospital).

What inspired you to start XDMD?

I have always been an engineer at heart. Building things and understanding how they work is what drives me. After years of research in medical imaging, I watched the field change fundamentally with the rise of AI. For many problems in medical imaging the question is no longer which methodology to publish, because we know what works. The question is whether it actually gets built and deployed. Can we get it to work in clinical practice and at scale? That combination, a drive to build and a field ready to be built, is what led me to start XDMD. It is highly motivating to know that what often starts at the whiteboard eventually ends up in products that improve the lives of patients.

How does XDMD approach challenges like data quality, regulation, and clinical integration?

Data is the hardest one. Collecting enough representative data and producing high quality reference standards is a real challenge. It also depends on what the client needs. For a proof of concept, a few datasets may be sufficient. For a product that needs to work globally at scale, it is a different problem entirely. In practice, clients often bring their own data, and there are publicly available datasets for many domains.

There are also commercial data brokers such as Segmed.ai that act as intermediaries between hospitals and companies.

Regulation depends on the TRL level and target market, but we account for it early in the process. We support clients in preparing technical documentation and software files, and where needed we bring in specialized partners. Clinical integration is the client’s responsibility. Our role is to develop the AI for the medical imaging component in their product. Getting that product to market is their domain.

How do you see AI transforming radiology and pathology in the next 5–10 years?

AI will continue to take over tasks in radiology and pathology. The market is already consolidating around platform-based solutions. And yet AI development in this domain never stops. New scanners and new and more imaging data, new clinical insights, new patient populations – a deployed model needs to be monitored, updated, and sometimes rebuilt from scratch. That means there will always be demand for people who know how to develop these systems. That is exactly what XDMD is here for.

Check them out
Startup spotlight

Cybosense

What if your sensor could heal itself, bend around your body and feel the world the way human skin does?

That’s exactly what Paula Montes Jiménez, biomedical engineer with a Master´s in Medical Device Design, is working on at Cybosense.

Current biosensors are rigid, toxic, expensive and can only detect a handful of parameters at a time; a fundamental bottleneck for the future of security, defence and precision agriculture.

Cybosense, a deep-tech spin-out from the DTU – Technical University of Denmark and with an office here at UtrechtInc, is flipping the script with AI-enabled, skin-inspired living electronic materials. Their sensors are:

🧬 Self-healing & adaptive
📍 Printable directly on skin
🌊 Wearable in motion & underwater
⚡ Multi-modal – sensing pressure, temperature, pH, and biomolecules simultaneously

This is what the next generation of sensing looks like; a material that lives with you.

👀 Watch the video, where Paula breaks this down for you!

Cybosense

Winner NL Startup Competition

Lumox

Lumox won the NL Startup Competition. ✨

The competition was held last week at Upstream Festival in Rotterdam, organized by Erasmus Centre for Entrepreneurship, one of the biggest startup competitions in the Netherlands, bringing together early-stage ventures from across the country. They will head to the Silicon Valley to visit Draper University.

Lumox is developing a cancer treatment that uses llama-derived nanobodies to deliver light-activatable drugs directly to tumor cells, then activates them with harmless light. Cancer cells destroyed. Healthy tissue spared. No disfiguring surgery. They are starting with head and neck cancer, where patients often face devastating treatment options or none at all.

This is the work of Irati Beltrán Hernández and Sebas Pronk. Years of research, preclinical validation, and real results in the veterinary clinic.

Lumox has been part of UtrechtInc´s community for a couple of years already.

Thank you Erasmus Entreprise and everyone at Upstream Festival for creating a space where science like this gets seen.

Startup spotlight

ObsessLess

ObsessLess – Building the Digital Support Layer for OCD

The Problem

OCD is one of the most disabling mental health conditions in the world, and one of the most misunderstood. In Europe alone, around 9 million adults live with active OCD each year. For many of them, it affects work, relationships, sleep, and confidence through intrusive thoughts, compulsions, avoidance, rumination, reassurance-seeking, checking, and the constant need to feel certain. The cost is enormous, estimated at €45 to €60 billion annually across Europe, but most of that burden doesn’t land inside healthcare systems. It falls on people, their families, employers, and caregivers.

People are already trying to get help. Out-of-pocket OCD support in Europe is estimated at €9 to €13 billion per year. Yet around 60% of people with active OCD received no mental health treatment in the past year. OCD care is too slow, too expensive, and too far removed from daily life.

The Solution

ObsessLess is building the digital support layer for OCD, not to replace therapy, but to make support available in the moments the current system can’t reach: before a first appointment, between sessions, after a trigger hits and the next session is still two weeks away.

Why Now?

Many people start searching for answers long before they ever reach a therapist. They look things up late at night, find communities, try to figure out quietly what is happening to them. Meanwhile healthcare systems are under more pressure than ever, specialist OCD care is hard to access, and many people never reach the right support at all. New technology makes it possible to reach people earlier and more continuously, at home, on waiting lists, between sessions, and in daily life.

What Makes ObsessLess Unique?

For many people with OCD, the first barrier is shame. Intrusive thoughts can feel confusing, embarrassing, or impossible to explain, and many people stay silent for months or years before asking for help. ObsessLess starts there, meeting people where they actually are: searching online, sitting on waiting lists, managing triggers alone. When someone finally understands what they’re dealing with, useful support should not be months/years away.

Meet the Team

Mourice Schuurmans is Co-Founder and CEO. He has 8+ years of experience building digital products, has lived with severe OCD himself, and built a 20K+ OCD advocacy community from scratch. He is also a member of the IOCDF AI Special Interest Group.

Adrian Pavel is Co-Founder and CTO, with 12+ years of experience in enterprise and consumer software, including previous roles at Shell and SoftVision.

Dr. Marina Gershkovich, PhD, ABPP, is Founding Clinical Advisor, a board-certified clinical psychologist and OCD researcher, formerly at Columbia University Medical Center’s Center for OCD and Related Disorders, with 15+ publications spanning OCD, telehealth, and mobile-app-supported care.

Follow ObsessLess on LinkedIn or visit obsessless.com to learn more.

 

Meet the Spring 2026 Science Validation Program Startups

Get ready to meet the Spring 2026 cohort of our Science Validation Program 🍂

🔸 ReduCO2
Team: Lotta Ternieten, Stefan Pitsch and Andreas Hettmann
Carbon conversion technology transforming CO₂ into durable raw materials. Designed to reduce atmospheric emissions while creating sustainable industrial resources.

🔸 ReFOLD
Team: Dr. Maarten Geurts, Dr. Else Driehuis, Prof. Ruben van Boxtel and Prof. Jeffrey Beekman

🔸 Subspacial
Team: Sagar Khavnekar and Jeremy Leitz
Spatial biology platform generating foundational subcellular data for advanced biological intelligence. Enables deeper understanding of cellular environments for research and therapeutic development.

🔸 ncPRIME
Team: Stijn van Breda Vriesman and Paul Schürmann
Biotechnology solution improving prime editing efficiency through chemically enhanced guide RNA. Advancing precision gene editing for more effective therapeutic applications.

Welcome all! ✨

Meet the Spring 2026 Tech Validation Program Startups

Get ready to meet the Spring 2026 cohort of our Tech Validation Program 🍂

🔸 Abakino
Team: Sohail Afiat
An intuitive whiteboard-based graphing tool that lets users solve equations and visualize functions through handwriting and gestures. Built to simplify STEM education by making advanced math interaction feel natural and accessible.

🔸 Neurobian
Team: Andrea Gasperini
Cognitive safety infrastructure that monitors real-time signals to detect risk and provide timely, adaptive AI assistance. Designed to make AI systems safer and more responsive in dynamic environments.

🔸 Tagetto
Team: Pieter Snelder
AI-powered deal sourcing and pipeline management platform for M&A professionals. Continuously enriches market data to create dynamic, real-time insights for deal origination.

🔸 OmicEdge
Team: Ian Simms & Jille van der Togt
Multi-omic health assessment, tracking and lifestyle modification guidance.

🔸 VlinderAI
Team: Ashwin Bilgi
AI agent infrastructure that enables solo founders and small teams to observe, debug, and repair production agents. Focused on improving reliability and speed in deploying AI-driven systems.

Welcome all! ✨

Startup spotlight

Hydrominds

Unlocking Mountain Water Data for Climate Resilience

There is no good data about water in mountains available; Hydrominds produces that data which helps to improve hydropower operations and helps investors and insurers to assess climate risks in mountains.

They are a climate-tech company that develops advanced tools and services to improve water resource management and disaster risk prediction in high mountain regions around the world.

They combine cutting-edge science, data and technology to deliver precise, data-driven insights on water availability, hydropower potential and climate-related risks. Their solutions such as their hydrological modeling platform help governments, businesses and organizations make better decisions around water, energy and climate resilience.

By turning complex mountain hydrology into actionable intelligence, Hydrominds supports sectors like agriculture, infrastructure and energy in becoming more efficient, resilient and prepared for the impacts of climate change.

Right now, their main focus is understanding the needs of the potential customer and obtaining initial funding.

About the team

Hydrominds was founded from a shared insight: the advanced models and data developed through years of mountain hydrology research could create far greater impact beyond academia. By taking a bottom-up approach, starting from real-world needs rather than purely scientific questions, the team is building practical tools for water management, hydropower and climate risk in mountain regions worldwide.

The founding team brings together deep expertise in climate science, hydrology and data-driven modelling. Sonu Khanal is a water resources expert and climate change specialist with over 14 years of global experience, leading projects on flood forecasting, drought risk, and climate resilience. Arthur Lutz, a hydrologist with 15 years of experience, focuses on mountain water systems and translates research into scalable, real-world solutions using advanced modelling, GIS and remote sensing.

They are complemented by Philip Kraaijenbrink, a physical geographer specializing in remote sensing, drone and satellite data, and large-scale environmental modelling, and Walter Immerzeel, a leading scientist and professor at Utrecht University with over 20 years of experience in climate change and mountain hydrology, recognized internationally for his pioneering research.

Together, the team combines academic excellence with hands-on project experience across Europe, Asia and Africa to develop impactful solutions for sustainable water management.

The founders, Arthur Lutz and Sonu Khanal answer some questions for us:

How does your background in (research field / discipline) shape the way you build this company?

We all have a background in research of mountain hydrology. Our shared passion for mountains is what has connected us over the last 10+ years, where some of us worked in academia and some in a small SME, but we always collaborated in one way or another. The background of working in an SME brings us good insights in how to run a small company, and also enables us to do some consulting work which enables us to self-fund our startup in the initial stages. Our research was at the highest level and now we also want to come up with the highest quality solutions for our clients.

What’s one early decision you’re glad you made even if it felt uncomfortable at the time?

For two of us one big decision was to quit our previous job completely to found hydrominds. This was a difficult decision to take, but also marked the start of this new adventure and enabled us to focus completely on the startup right from the beginning.

If things go well over the next 12 months, what would ‘progress’ look like for you?

If things go well over the next 12 months, we get some of the seed funding proposals we recently submitted, and have successfully piloted a first prototype of our solution with a hydropower company in Nepal. That should confirm that our value proposition is valid and we can move on from there. Ideally we are also able to expand the team by then to speed up things.

Tim Sakkers Wins Young Innovator Award 2026 | UtrechtInc Startup

Tim Sakkers Wins Young Innovator Award 2026

We are proud to share that Tim Sakkers, founder of ReveltaDx and a participant in the UtrechtInc Science Validation Program, has won the Young Innovator Award 2026 at Innovation for Health. The award recognises promising innovations with strong potential to impact healthcare.

Building ReveltaDx
ReveltaDx focuses on improving the diagnosis of heart disease in women — an area where current diagnostic approaches often fall short. By addressing this gap, the startup aims to contribute to more accurate and timely diagnosis, supporting better healthcare outcomes.

The role of validation
Tim participated in the UtrechtInc Science Validation Program in 2025, where he worked on validating the core assumptions behind his idea.

This phase is essential for early-stage founders, helping them:

  • Test their concept with real stakeholders
  • Understand the problem space more deeply
  • Refine their value proposition
  • Build a foundation for further development

Winning the Young Innovator Award marks an important milestone in the journey of ReveltaDx. It highlights how early validation, combined with continued development, can lead to meaningful recognition and progress.

Nestpod: Validation to Adoption | UtrechtInc Startup

 Nestpod: From idea to real-world impact


Nestpod®, a UtrechtInc Tech Validation graduate, is taking its next step after a strong validation phase at the Negenmaandenbeurs.

During the event, the team tested their solution directly with users, mothers looking for safe, private spaces for breastfeeding and pumping. The response was immediate and consistent: the pod was used continuously throughout the day, with queues forming at peak moments.

Through conversations, observations, and feedback from over 170 users, one thing became clear:
there is a clear and urgent need for better lactation facilities, both at work and in public spaces.

Access to proper lactation spaces remains limited. While this is often seen as a “nice-to-have,” the reality is different.

A significant number of mothers are not satisfied with existing facilities, which can impact wellbeing, workplace experience, and long-term retention. The demand observed during validation highlights how actively such solutions are valued when they are available.

Following the validation phase, Nestpod has moved into real-world deployment.

The pod is currently placed at SV Kampong in Utrecht, where organisations can experience it in practice. At the same time, companies have already started exploring how to implement the solution in their own environments.

👉 Nestpod is now available to order, with a delivery time of approximately six weeks.
👉 A flexible rental option is also available.

Why this matters
Nestpod is a strong example of what early validation can achieve:

  • Testing with real users
  • Gathering actionable feedback
  • Demonstrating clear demand
  • Moving quickly towards adoption
  • It reflects the importance of building solutions based on real needs and validating them early.

We’re very happy about this and always here to support such initiatives!

Toastie Talk 09.03

Navigating the 2026 Startup Landscape: Insights from UtrechtInc

Recent Trends in the (Dutch) Startup Ecosystem

At the March edition of our Toastie Talk, Stefan explored the evolving trends shaping the Dutch and European startup ecosystems. Based on an analysis of six major industry reports (including Draghi, Dealroom and Techleap), here is what founders need to know:

  • Strategic Focus on Deep Tech: There is a strong push from both the EU and the Dutch government to prioritize “deep tech”, innovations in quantum computing, biotech, and clean energy that require long-term investment but offer significant impact.
  • Support for Academic Spin-outs: Policy is moving toward making it easier to translate university research into viable commercial entities, with streamlined IP and licensing processes.
  • Addressing the “Valley of Death”: While early-stage support is robust, the real challenge remains scaling. UtrechtInc and its network are focused on providing the mentorship and commercial strategy needed to survive this critical phase.
  • Shifting Investor Expectations: Funding is available, but early-stage investors are becoming more selective, prioritizing startups that can demonstrate clear value creation over mere product development.
  • The Importance of Ecosystem: Success in 2026 requires more than just a great idea; it requires a supportive network of investors, experienced mentors, and a founder mindset that “plays to win” on a global stage.